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This aligns with evidence that mitochondrial fission can proceed without changes in DRP1 expression, such as with deletion of PTEN-induced kinase 1 or protein kinase A activation, which affect DRP1 phosphorylation at Ser616 without altering protein levels [61, 62]

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Antioxidants (Basel) (2020) 9:1070

Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation

doi: 10.3389/fimmu.2019.01462 137

Histologically this widespread reaction does not have the picture of contact dermatitis but frequently presents the picture of a lymphocytic vasculitis